PDE10A Antibody (1B2)

Images

 
Western Blot: PDE10A Antibody (1B2) [NBP1-47908] Analysis of extracts (35ug) from 9 different cell lines by using anti-PDE10Amonoclonal antibody.
Immunohistochemistry-Paraffin: PDE10A Antibody (1B2) [NBP1-47908] - Staining of paraffin-embedded endometrium tissue using anti-PDE10A mouse monoclonal antibody.
Western Blot: PDE10A Antibody (1B2) [NBP1-47908] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE10A(Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-47908
    • Availability
      Product Discontinued

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PDE10A Antibody (1B2) Summary

Immunogen
Protein expressed in 293T cell transfected with human PDE10A expression vector
Specificity
This antibody is specific for Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PDE10A
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for PDE10A Antibody (1B2)

  • cAMP and cAMP-inhibited cGMP 3'-5'-cyclic phosphodiesterase 10A
  • dJ416F21.1 (phosphodiesterase 10A)
  • EC 3.1.4
  • EC 3.1.4.17
  • EC 3.1.4.35
  • FLJ11894
  • FLJ25677
  • HSPDE10A
  • phosphodiesterase 10A
  • phosphodiesterase 10A1 (PDE10A1)

Background

Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PDE10A
Entrez