PD-L2/B7-DC/PDCD1LG2 Antibody (TY25) [Biotin] Summary
B7-DC transfected RAW264.7 cells.
NB100-65332 recognizes mouse CD273, a 42kD member of the B7 family, otherwise known as B7-dendritic cell (B7-DC), or programmed death ligand-2 (PD-L2). The expression of CD273 is restricted to a subpopulation of dendritic cells (DCs), and DCs and macrophages that have been stimulated with interferon gamma, GM-CSF or IL-4. CD273 has been identified as a ligand for PD-1(CD279), along with another B7 family member B7-H1 (CD274). Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production. Antibodies produced by clone TY25 are reported to block the binding of CD273 (B7-DC) to it's receptor.
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Biotin (A=N/A, E=N/A)
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
0.09% Sodium Azide
Protein G purified
Alternate Names for PD-L2/B7-DC/PDCD1LG2 Antibody (TY25) [Biotin]
- Butyrophilin B7-DC
- Butyrophilin-like Protein
- CD273 antigen
- CD273PD-1 ligand 2
- PD-1-ligand 2
- PD-L2PDCD1 ligand 2
- programmed cell death 1 ligand 2
- Programmed death ligand 2
The TY25 monoclonal antibody reacts with mouse B7-DC/PD-L2. B7-DC, a member of the B7 family, has a predicted molecular weight of ~25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Species: Hu, Mu
Applications: WB, IHC
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
Species: Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Cell Depl, InhibTFunc
Applications: WB, Flow, AgAct
Species: Hu, Mu, Rt, Po, Bv
Applications: WB, ICC/IF
Applications: WB, AgAct
Publications for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504) (0)
There are no publications for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504) (0)
There are no reviews for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504).
By submitting a review earn points towards our Rewards Program.
- 250 points for product review
- 500 additional points for an image with your product review
- Double points (500) if you are the first to review this product
- Double points (1000) if you are the first to review this product with an image
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504) (0)
Additional PD-L2/B7-DC/PDCD1LG2 Products
Related Products by Gene
Bioinformatics Tool for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504)
Discover related pathways, diseases and genes to PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
PTMs for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504)
Learn more about PTMs related to PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-43504).
Blogs on PD-L2/B7-DC/PDCD1LG2