PD-L2/B7-DC/PDCD1LG2 Antibody (122)

Images

 
Flow Cytometry: PD-L2/B7-DC/PDCD1LG2 Antibody (122) [NBP1-43116] - Analysis using the FITC conjugate of NBP1-43116. Staining of In vitro BALB/c mouse bone marrow-derived dendritic cells with 0.25 ug of Rat IgG2a kappa ...read more
Flow Cytometry: PD-L2/B7-DC/PDCD1LG2 Antibody (122) [NBP1-43116] - Analysis using the Biotin conjugate of NBP1-43116. Staining of in vitro BM-derived dendritic cells from BALB/c with 0.06 ug of Rat IgG2a Isotype Control ...read more
Flow Cytometry: PD-L2/B7-DC/PDCD1LG2 Antibody (122) [NBP1-43116] - Analysis using the PE conjugate of NBP1-43116. Staining of in vitro bone marrow-derived dendritic cells from BALB/c mice with 0.125 ug of Rat IgG2a ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
122
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

PD-L2/B7-DC/PDCD1LG2 Antibody (122) Summary

Immunogen
The immunogen for this antibody was B7DC.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
PDCD1LG2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
The 122 antibody has been tested by flow cytometric analysis of mouse dendritic cell suspensions and mouse B7-DC transfected cells. This can be used at less than or equal to 0.5 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous, may contain carrier protein/stabilizer.
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for PD-L2/B7-DC/PDCD1LG2 Antibody (122)

  • B7-DC
  • bA574F11.2
  • Btdc
  • Butyrophilin B7-DC
  • Butyrophilin-like Protein
  • CD273 antigen
  • CD273
  • CD273PD-1 ligand 2
  • MGC142240
  • PD-1-ligand 2
  • PDCD1L2MGC142238
  • PDCD1LG2
  • PDL2
  • PD-L2
  • PDL2B7DC
  • PD-L2PDCD1 ligand 2
  • programmed cell death 1 ligand 2
  • Programmed death ligand 2

Background

The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25, another mAb specific for mouse B7-DC.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

PE Labeled NBP1-43702

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Bioinformatics

Gene Symbol PDCD1LG2
Entrez