Pax3 Antibody (C2)

Images

 
Western Blot: PAX3 Antibody (C2) [NBP1-19197] - PAX3 Antibody (C2) 624 Mel nuclear lysates probed with Pax-3 Monoclonal Antibody (C2) at 1 ug/mL

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
C2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Pax3 Antibody (C2) Summary

Immunogen
Synthetic peptide derived from a sequence near the carboxy-terminus of quail Pax-3
Specificity
Pax3 (C2)
Isotype
IgG2
Clonality
Monoclonal
Host
Mouse
Gene
PAX3
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
Sodium Azide
Purity
Protein G purified

Alternate Names for Pax3 Antibody (C2)

  • CDHS
  • HUP2
  • HUP2MGC120384
  • MGC120381
  • MGC120382
  • MGC120383
  • MGC134778
  • paired box 3
  • paired box gene 3 (Waardenburg syndrome 1)
  • paired box homeotic gene 3
  • paired box protein Pax-3
  • paired domain gene 3
  • paired domain gene HuP2
  • Pax3
  • Waardenburg syndrome 1
  • WS1
  • WS3

Background

Pax3 is a member of the paired box family of nuclear transcription factors that function in the transcriptional control of pattern development during embryogenesis. Pax3 is characterized by a conserved N-terminal paired box DNA binding domain, and a C-terminal transcriptional activation domain. In humans, loss of function mutations in Pax3 are associated with type I and type III Waardenburg Syndrome, characterized by varying degrees of developmental abnormalities in facial structure, pigmentation, limb development, and hearing. Translocation t(2;13) of the Pax3 loci to the fork head (FKHR) transcription factor gene results in the creation of a Pax3-FKHR fusion gene with transcriptional hyperactivity manifested in alveolar rhabdomyosarcoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Pax3 Antibody (NBP1-19197)

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Blogs on Pax3.

FOXO1/FKHR (fork head in Rhabdomyosarcoma)
FOXO1 belongs to the very large Forkhead family of transcription factors which contain a conserved distinct DNA-binding domain known as the Forkhead Box, or FOX. The Forkhead domain is a 100 amino acid long motif capable of binding and bending DNA,...  Read full blog post.

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Bioinformatics

Gene Symbol PAX3
Entrez