Patched 1/PTCH Antibody (413220) [Biotin]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-61244B
    • Availability
      Product Discontinued

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Patched 1/PTCH Antibody (413220) [Biotin] Summary

Immunogen
E. coli-derived recombinant mouse Patched 1/PTCH
Glu108-Asp422
Accession # Q61115
Specificity
Detects mouse Patched 1/PTCH (First Extracellular Loop) in direct ELISAs and Western blots. In direct ELISAs and Western blots, 15% cross‑reactivity with recombinant human Patched 2 is observed.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
PTCH1
Purity
Affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS.
Preservative
0.05% Sodium Azide
Purity
Affinity purified

Alternate Names for Patched 1/PTCH Antibody (413220) [Biotin]

  • BCNS
  • BCNSFLJ42602
  • FLJ26746
  • HPE7
  • mes
  • NBCCS
  • patched (Drosophila) homolog
  • Patched 1
  • patched homolog (Drosophila)
  • patched homolog 1 (Drosophila)
  • patched homolog 1
  • protein patched homolog 1
  • PTC
  • ptc1
  • PTCH protein +12b
  • PTCH protein +4'
  • PTCH protein -10
  • PTCH
  • PTCH1
  • PTCH11

Background

Patched homolog 1 (PTCH, also called PTC, PTC1 or PTCH1) is a 170 175 kDa member of the Patched family of proteins. It is found on multiple cells types and forms a constitutive, inactivating complex with Smoothened. Upon SHH binding to PTC1, Smoothened is released and initiates downstream signaling. Mouse PTCH is a 12 transmembrane, 1434 aa glycoprotein that contains two terminal cytoplasmic domains. Only one mRNA species for PTCH has been reported in mice. However, it would appear likely that two or more splice forms exist, with variation occurring over the first 150 aa of the N-terminus. Over aa 108 NBP2-61244B422, mouse PTCH shares 97% and 99% aa sequence identity with human and rat PTCH, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Patched 1/PTCH Antibody (NBP2-61244B). (Showing 1 - 1 of 1 FAQ).

  1. I need a proven anti-human Ptch1 antibody that maps C-terminus of Ptch1 protein which is thus appropriate for all isoforms of human Ptch1 protein. Can you please suggest any which can be used for Western blotting?
    • NB100-41101 is expected to recognize all isoforms. NBP2-19705, NBP1-71662, 21130002, and NBP1-59455 should all suit your needs as well. Further details about each product can be found on their individual datasheets.

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Diseases for Patched 1/PTCH Antibody (NBP2-61244B)

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Bioinformatics

Gene Symbol PTCH1
Entrez