PAR1/Thrombin Receptor Antibody

Images

 
Immunohistochemistry-Paraffin: PAR1/Thrombin Receptor Antibody [NLS2583] - Analysis of anti-F2R / Thrombin Receptor / PAR1 antibody with human liver.
Immunohistochemistry-Paraffin: PAR1/Thrombin Receptor Antibody [NLS2583] - Analysis of anti-F2R / Thrombin Receptor / PAR1 antibody with bone marrow, megakaryocyte
Immunohistochemistry-Paraffin: PAR1/Thrombin Receptor Antibody [NLS2583] - Analysis of anti-F2R / Thrombin Receptor / PAR1 antibody with skeletal muscle at dilution 40 ug/ml.

Product Details

Summary
Reactivity Hu, MkSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

PAR1/Thrombin Receptor Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human Thrombin Receptor.
Localization
Membrane; multi pass membrane protein.
Specificity
Human Thrombin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Monkey (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
F2R
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 17-23 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Baboon (94%), Gorilla (89%), Gibbon (89%), Marmoset (83%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PAR1/Thrombin Receptor Antibody

  • Cf2r
  • CF2RHTR
  • coagulation factor II (thrombin) receptor
  • Coagulation factor II receptor
  • F2R
  • HTR
  • PAR1
  • PAR1PAR-1protease-activated receptor 1
  • Protease-Activated Receptor 1
  • Thrombin receptor
  • ThrR
  • TRGPC
  • TRproteinase-activated receptor 1

Background

Thrombin Receptor is a Proteinase-Activated Receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. Thrombin induced RANTES expression through a PAR-1 mediated pathway influences inflammatory cell migration to the synovium in patients with rheumatoid arthritis. Thrombin Receptor expression has been documented in various blood cells, colon, kidney, liver, lung, skin, and vessel. ESTs have been isolated from adrenal, embryo, heart, heart/melanocyte/uterus, liver/spleen, pineal, skin, spleen, and vessel.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol F2R
Entrez