PAR1/Thrombin Receptor Antibody

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Western Blot: PAR1/Thrombin Receptor Antibody [NBP1-51488] - Extracts from hela cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51488
    • Availability
      Product Discontinued

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PAR1/Thrombin Receptor Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 12-60 of Human Thrombin R.
Specificity
Thrombin R (S42) pAb detects endogenous levels of Thrombin R protein.
Clonality
Polyclonal
Host
Rabbit
Gene
F2R
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analyzes of Thrombin R (S42) pAb in extracts from hela cells.
Theoretical MW
48 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PAR1/Thrombin Receptor Antibody

  • Cf2r
  • CF2RHTR
  • coagulation factor II (thrombin) receptor
  • Coagulation factor II receptor
  • F2R
  • HTR
  • PAR1
  • PAR1PAR-1protease-activated receptor 1
  • Protease-Activated Receptor 1
  • Thrombin receptor
  • ThrR
  • TRGPC
  • TRproteinase-activated receptor 1

Background

Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface receptors. These receptors, including thrombin receptor (also designated PAR-1, for protease-activated receptor-1), PAR-2 and PAR-3 are members of the G-protein coupled receptor family, and share a similiar gene structure. Thrombin cleaves its receptor, releasing a 41 amino acid peptide which acts as a platelet agonist. Upon this activation by thrombin, the thrombin receptors trigger an increase in cytosolic Ca2+ concentration. Unactivated thrombin receptor cycles between the cell surface and an intracellular pool, while activated receptor internalizes rapidly and is degraded in the lysosomes. The human thrombin receptor is also known to be regulated by Sp1 and Sp3 transcription factors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol F2R
Entrez