p70 S6 Kinase/S6K [p Ser235, p Ser236] Antibody (SP50)

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Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Thymus
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Breast Carcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Breast Ductal Cell Carcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Bladder Transitional Cell Carcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Colon Adenocarcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Hepatocellular Cell Carcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Lung Adenocarcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Lung Squamous Cell Carcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Renal Cell Carcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Stomach Adenocarcinoma
Immunohistochemistry-Paraffin: p70 S6 Kinase/S6K [p ser235, p Ser236] Antibody (SP50) [NBP1-49813] - Human Tonsil

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
SP50
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

p70 S6 Kinase/S6K [p Ser235, p Ser236] Antibody (SP50) Summary

Immunogen
Synthetic peptide derived from the region of human S6 ribosomal that contains phosphorylated serines 235 and 236
Modification
p Ser235, p Ser236
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
RPS6KB1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This product is useful for Immunohistochemistry Paraffin. Antigen retrieval can be performed using a na process.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
7.0 ml prediluted antibody with 10mM PBS (pH 7.4) and 1.0% BSA
Preservative
0.1% Sodium Azide
Purity
Protein A or G purified

Notes

For a positive control use Breast carcinoma.

Alternate Names for p70 S6 Kinase/S6K [p Ser235, p Ser236] Antibody (SP50)

  • EC 2.7.11
  • EC 2.7.11.1
  • p70 ribosomal S6 kinase alpha
  • p70 S6 kinase alpha
  • p70 S6 Kinase
  • p70 S6 kinase, alpha 1,70 kDa ribosomal protein S6 kinase 1
  • p70 S6 kinase, alpha 2
  • p70 S6KA
  • p70 S6K-alpha
  • p70(S6K)-alpha
  • p70-alpha
  • p70-S6K
  • P70S6K1
  • PS6K
  • ribosomal protein S6 kinase beta-1
  • Ribosomal protein S6 kinase I
  • ribosomal protein S6 kinase, 70kD, polypeptide 1
  • ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • RPS6KB1
  • S6K
  • S6K1
  • S6K1p70-S6K 1
  • S6K-beta-1
  • serine/threonine kinase 14 alpha
  • Serine/threonine-protein kinase 14A
  • STK14A

Background

p70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Blogs on p70 S6 Kinase/S6K.

S6K - a serine/threonine kinase with diverse roles in cell survival and cell cycle progression
S6K is a serine/threonine kinase that is a member of the ribosomal S6 kinase (RSK) family. S6K exists in two main isoforms, S6K1 and S6K2, which can also be alternatively spliced to produce different splice forms. S6K1 has two major splicing produ...  Read full blog post.

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Bioinformatics

Gene Symbol RPS6KB1
Entrez