p70 S6 Kinase/S6K [p Ser371] Antibody (EPR2132)

Images

 
Western Blot: S6K [p Ser371] Antibody (EPR2132) [NBP1-96072] 293T cell lysate. Cells were either (A) untreated or (B) treated with Alkaline Phosphatase (AP).

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-96072
    • Availability
      Product Discontinued

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p70 S6 Kinase/S6K [p Ser371] Antibody (EPR2132) Summary

Immunogen
A phospho specific peptide corresponding to residues surrounding serine 371 of human p70 S6 Kinase was used as an immunogen.
Modification
p Ser371
Specificity
This antibody only detects p70 S6 Kinase phosphorylated at serine 371.
Clonality
Monoclonal
Host
Rabbit
Gene
RPS6KB1
Purity
Tissue culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000 - 10000

Reactivity Notes

Reacts with: Mouse, Rat, Human

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
49% PBS, 0.05% BSA and 50% Glycerol
Preservative
0.01% Sodium Azide
Purity
Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for p70 S6 Kinase/S6K [p Ser371] Antibody (EPR2132)

  • EC 2.7.11
  • EC 2.7.11.1
  • p70 ribosomal S6 kinase alpha
  • p70 S6 kinase alpha
  • p70 S6 Kinase
  • p70 S6 kinase, alpha 1,70 kDa ribosomal protein S6 kinase 1
  • p70 S6 kinase, alpha 2
  • p70 S6KA
  • p70 S6K-alpha
  • p70(S6K)-alpha
  • p70-alpha
  • p70-S6K
  • P70S6K1
  • PS6K
  • ribosomal protein S6 kinase beta-1
  • Ribosomal protein S6 kinase I
  • ribosomal protein S6 kinase, 70kD, polypeptide 1
  • ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • RPS6KB1
  • S6K
  • S6K1
  • S6K1p70-S6K 1
  • S6K-beta-1
  • serine/threonine kinase 14 alpha
  • Serine/threonine-protein kinase 14A
  • STK14A

Background

p70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Blogs on p70 S6 Kinase/S6K.

S6K - a serine/threonine kinase with diverse roles in cell survival and cell cycle progression
S6K is a serine/threonine kinase that is a member of the ribosomal S6 kinase (RSK) family. S6K exists in two main isoforms, S6K1 and S6K2, which can also be alternatively spliced to produce different splice forms. S6K1 has two major splicing produ...  Read full blog post.

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Bioinformatics

Gene Symbol RPS6KB1
Entrez
Uniprot