p66 beta Antibody

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Immunohistochemistry-Paraffin: p66 beta Antibody [NBP1-52546] - Analysis of anti-GATAD2B antibody with human adrenal at concentration 3.75 ug/ml.
Immunohistochemistry-Paraffin: p66 beta Antibody [NBP1-52546] - Analysis of anti-GATAD2B antibody with human spleen at concentration 3.75 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bt, Bv, Ca, Eq, Ha, Mk, Pm, Rb, Op, ZeSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

p66 beta Antibody Summary

Immunogen
Synthetic peptide from human GATAD2B.
Specificity
Human GATAD2B.
Predicted Species
Opossum (100%), Zebrafish (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
GATAD2B
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 3.75 ug/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Stickleback (92%), Xenopus (83%), Pufferfish (83%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for p66 beta Antibody

  • FLJ37346
  • GATA zinc finger domain containing 2B
  • GATA zinc finger domain-containing protein 2B
  • KIAA1150
  • MGC138257
  • MGC138285
  • p66/p68
  • P66beta
  • RP11-216N14.6
  • transcription repressor p66 beta component of the MeCP1 complex
  • transcriptional repressor p66-beta

Background

Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic genomes (1-3). Increasing evidence indicates that recruitement of histone deacetylase complexes by methyl-CpG-binding proteins (MeCP) is a major mechanism of methylated DNA silencing. P66, a zinc finger-containing protein is one of the components of the MeCP1 complex (4). P66 and p68, the two components of MeCP1 are different forms of the same zinc finger-containing protein and are conserved from C.elegans to humans. Homologs of p66 from different organisms revealed two highly conserved regions, CR1 and CR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2 plays an important role in targeting p66 and MBD3 to specific loci (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GATAD2B
Entrez
Uniprot