20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol
>90%, by SDS-PAGE
39.7 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
This is a Human protein. Mouse reactivity reported in scientific literature (PMID; 21460622)
The purity of this protein is > 90% by SDS-PAGE. Molecular weight is 39.7 kDa (364aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Alternate Names for p62/SQSTM1 Recombinant Protein
EBI3-associated protein of 60 kDa
EBI3-associated protein p60
oxidative stress induced like
Paget disease of bone 3
phosphotyrosine independent ligand for the Lck SH2 domain p62
Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
Ubiquitin-binding protein p62
p62/SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 protein commonly cause Paget's disease since the UBA is necessary for aggregate sequestration and cell survival. Recombinant p62/SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
p62/SQSTM1 (sequestosome 1) p62/SQSTM1 (sequestosome 1) is ubiquitously-expressed cytoplasmic/adaptor protein. SQSTM1 functions as a signaling hub for various signal transduction pathways involved in apoptosis, cell differentiation, apoptosis, immune response, and K+ channel reg... Read full blog post.