p38 alpha Antibody

Product Discontinued

p38 alpha Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 142-196 of Human p38.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MAPK14
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analyzes of p38 (H174) pAb in extracts from 3T3 cells.
  Immunohistochemistry (IHC) analyzes of p38 (H174) pAb in paraffin-embedded human brain tissue.
• Theoretical MW: 42 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for p38 alpha Antibody

• CSBP;CSBP1;CSBP2;CSPB1;EXIP;MAPK14;Mitogen-activated protein kinase;Mitogen-activated protein kinase 14;Mxi2;p38;p38ALPHA;PRKM14;PRKM15;RK;SAPK2A
• MAPK14
• p38 alpha
• SAPK2a

Background

Drosophila melanogaster is a proven and effective model for studying developmental and cellular processes common to higher eukaryotes. Approximately 13,600 genes have been elucidated from more than 120 megabases of euchromatin, and they are organized among the chromosomes 2, 3, 4, X and Y, with the Y chromosome being predominately heterochromatic. Drosophila genes can be categorized based on the type of protein for which they encode. They are represented by six major classifications, which include intracellular signaling proteins, transmembrane proteins, RNA binding proteins, secreted factors, transcription regulators (basic helix-loop-helix, homeodomain containing, zinc finger containing, and chromatin associated) or other functional proteins. Many of the genes expressed in Drosophila are structurally and functionally similar across species, as are the pathways involved in transducing intracellular signaling. Among these pathways, the p38 protein, which is the stress-activated p38beta component of the MAP kinase pathway, functions in Drosophila similarly to its role as a serine/threonine protein kinase in mammalian cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for p38 Antibody (NBP1-19820)(1)

Publication using NBP1-19820

• Pal S, Nath P, Biswas S et al. Nonylphenol attenuates SOCS3 expression and M1 polarization in lipopolysaccharide-treated rat splenic macrophages Ecotoxicol. Environ. Saf. 2019-06-15 [PMID: 30870658] (WB, Rat)

Bioinformatics

• Gene Symbol: MAPK14
• Entrez:
  • 1432(Human)
  • 26416(Mouse)
  • 81649(Rat)
• Uniprot:
  • Q16539()