Western Blot: p27/Kip1 Antibody [NB100-82093] - Analysis using p27Kip1 antibody: Lane1: The extract from A2780 cells; Lane2: The extract from COLO20 degrees Cells; Lane3: The extract from COLO20 degrees Cells using ...read more
Immunohistochemistry: p27/Kip1 Antibody [NB100-82093] - Analysis of paraffin-embedded human lung carcinoma tissue using p27Kip1 (Ab-10) antibody.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.