p18INK4c/CDKN2C Antibody

Images

 
Western Blot: p18INK4c/CDKN2C Antibody [NB100-91907] - p18 INK (D142) pAb in extracts from hela cells.
Immunohistochemistry-Paraffin: p18INK4c/CDKN2C Antibody [NB100-91907] - Human breast carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-91907
    • Availability
      Product Discontinued

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p18INK4c/CDKN2C Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human p18 INK4c.
Clonality
Polyclonal
Host
Rabbit
Gene
CDKN2C
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of p18 INK (D142) pAb in extracts from hela cells.
Immunohistochemistry (IHC) analysis of p18 INK (D142) pAb in paraffin-embedded human breast carcinoma tissue
Theoretical MW
18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for p18INK4c/CDKN2C Antibody

  • CDK6 inhibitor p18
  • CDKN2C
  • CDKN6
  • cyclin-dependent inhibitor
  • cyclin-dependent kinase 4 inhibitor C
  • Cyclin-dependent kinase 6 inhibitor
  • cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
  • INK4Ccyclin-dependent kinase 6 inhibitor p18
  • p18
  • p18INK4c
  • p18-INK4C
  • p18-INK6

Background

The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6 which are subject to inhibition by the mitotic inhibitory protein p16. Isolated members of the p16 family have been designated p15 and p18, respectively. The p16 related protein, p18, interacts strongly with Cdk6 and to a lesser extent with Cdk4, but lacks apparent interaction with other Cdks. Recombinant p18 has been shown to inhibit cyclin D-Cdk6 kinase activity. In contrast to p21/p27 that form ternary complexes with cyclin-Cdks, only binary complexes of p15, p16 and p18 have been identified in association with Cdk4 and/or Cdk6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CDKN2C
Entrez