p14ARF/CDKN2A Antibody

Images

 
Immunohistochemistry-Paraffin: p14ARF Antibody [NB200-355] - Formalin fixed paraffin embedded human cervical cancer stained with p14ARF antibody.

Product Details

Summary
Product Discontinued
View other related p14ARF/CDKN2A Primary Antibodies

Order Details


    • Catalog Number
      NB200-355
    • Availability
      Product Discontinued

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p14ARF/CDKN2A Antibody Summary

Immunogen
Synthetic peptide derived from the C-terminus of human p14ARF protein.
Specificity
Detects a band at 11kD
Clonality
Polyclonal
Host
Rabbit
Gene
CDKN2A
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
Immunohistochemistry formalin fixed paraffin embedded / frozen sections: use in an ABC method. Optimal dilutions / concentrations should be determined by the end user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
Positive Control
p16 Lysate (NBL1-09052)
Publications
Read Publications using
NB200-355 in the following applications:

  • IHC
    1 publication

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
Sodium Azide
Purity
Protein A purified

Alternate Names for p14ARF/CDKN2A Antibody

  • ARF
  • CDK4 inhibitor p16-INK4
  • CDK4I
  • CDK4IP14ARF
  • CDKN2
  • CDKN2A
  • cell cycle negative regulator beta
  • CMM2P16-INK4A
  • Cyclin-dependent kinase 4 inhibitor A
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • cyclin-dependent kinase inhibitor 2A
  • INK4
  • INK4a
  • MLM
  • MLMP16INK4
  • MTS-1
  • MTS1P14
  • Multiple tumor suppressor 1
  • p14
  • p14ARF
  • p16
  • p16-INK4
  • p16INK4a
  • p16-INK4a
  • P19
  • p19ARF
  • TP16

Background

The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein, ARF (p14ARF in human and P19ARF in mouse). These two proteins interact with the upstream proteins: retinoblastoma protein and p53 tumor suppressors, respectively. Each of these proteins has a role in the senescence of primary cells, activates pathways for cell cycle control and tumor suppression. The p14ARF (or P19ARF in mouse) proteins can induce both G1 and G2 phase arrest in a manner that depends on functional p53. The mouse and human ARF proteins have different functions in tumor suppression; this distinction may contribute to the different levels of tumor proneness of these species.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for p14ARF/CDKN2A Antibody (NB200-355)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC.


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IHC
(1)
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Filter By Species
Human
(1)
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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional p14ARF/CDKN2A Products

p14ARF/CDKN2A NB200-355

Bioinformatics Tool for p14ARF/CDKN2A Antibody (NB200-355)

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Diseases for p14ARF/CDKN2A Antibody (NB200-355)

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PTMs for p14ARF/CDKN2A Antibody (NB200-355)

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Bioinformatics

Gene Symbol CDKN2A
Entrez