p130Cas/BCAR1 Antibody

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Immunohistochemistry-Paraffin: p130Cas/BCAR1 Antibody [NBP1-19421] - Human breast carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-19421
    • Availability
      Product Discontinued

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p130Cas/BCAR1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 140-180 of Human p130 Cas.
Specificity
p130 Cas (P160) detects endogenous levels of p130 Cas protein.
Clonality
Polyclonal
Host
Rabbit
Gene
BCAR1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Immunohistochemistry (IHC) analyzes of p130 Cas (P160) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
130 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for p130Cas/BCAR1 Antibody

  • BCAR1
  • breast cancer estrogen resistance 1
  • Cas scaffolding protein family member 1
  • CAS1
  • CASFLJ45059
  • CASS1
  • CASS1CRKASbreast cancer estrogen resistance protein 1
  • CRKAS
  • Crk-associated substrate p130Cas
  • CRK-associated substrate
  • FLJ12176
  • p130Cas

Background

Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol BCAR1
Entrez