p130 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: p130 Antibody [NBP1-61536] - Analysis of HeLa cells, using p130 Antibody. The picture on the right is treated with the synthesized peptide.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-61536
    • Availability
      Product Discontinued

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p130 Antibody Summary

Immunogen
The antiserum was produced against synthesized peptide derived from human RBL2. The immunogen region is: C-terminal.
Specificity
RBL2 (Ab-952) Antibody detects endogenous levels of total RBL2 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
RBL2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:1000
  • Immunocytochemistry/Immunofluorescence 1:100-1:500

Reactivity Notes

Human,Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for p130 Antibody

  • FLJ26459
  • P130
  • PRB2
  • Rb2
  • RBR-2
  • retinoblastoma-like 2 (p130)
  • retinoblastoma-like protein 2,130 kDa retinoblastoma-associated protein
  • Retinoblastoma-related protein 2

Background

p130 Cas (Crk-associated substrate) is a 120-130 kD docking protein and a central coordinator for tyrosine-kinase-based signaling related to cell adhesion. p130 Cas has been implicated in induction of cell migration, growth factor stimulation, cytokine receptor engagement, cardiovascular development, and actin filament assembly. p130 Cas is localized to focal adhesions and stress fibers. When unphosporylated, localizes in the cytoplasm; phosphorylation by FAK induces movement to membrane. p130 Cas is dephosphorylated by PTP-PEST, dephosphorylation blocks cell migration. p130 Cas has been reported to interact with v-Crk, v-Src, nephrocystin, PTK2B, CrkII and to form complexes with Fak1, CrkL, and Lyn kinase and to heterodimerize with CasL. The Poly6139 antibody recognizes the C-terminal region of human p130 Cas and has been shown to be useful for Western blotting. v-Crk, v-Src, nephrocystin, PTK2B, CrkII. Forms complexes with Fak1, CrkL, Lyn kinase; heterodimerizes with CasL

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol RBL2
Uniprot