p120-catenin Antibody (SP63)

Images

 
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] - Human Esophagus stained with anti-p120 antibody
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] Human Breast Carcinoma
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] - Human Bladder Transitional Cell Carcinoma stained with anti-p120 antibody
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] - Human Cervical Squamous Cell Carcinoma stained with anti-p120 antibody
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] - Human Cervix stained with anti-p120 antibody
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] - Human Colon Adenocarcinoma stained with anti-p120 antibody
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] - Human Hepatocellular Carcinoma stained with anti-p120 antibody
Immunohistochemistry-Paraffin: p120-catenin Antibody (SP63) [NBP1-49823] - Human Stomach Adenocarcinoma stained with anti-p120 antibody

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
SP63
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

p120-catenin Antibody (SP63) Summary

Immunogen
Synthetic peptide from the C-terminus of human p120
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
CTNND1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This product is useful for Immunohistochemistry Paraffin. Antigen retrieval can be performed using a na process.
Theoretical MW
108 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS/1% BSA buffer pH 7.6
Preservative
Sodium Azide
Purity
Protein A or G purified

Notes

For a positive control use Breast carcinoma.

Alternate Names for p120-catenin Antibody (SP63)

  • Cadherin-associated Src substrate
  • CAS
  • catenin (cadherin-associated protein), delta 1
  • catenin delta-1
  • CTNND
  • KIAA0384P120CAS
  • p120 catenin
  • p120
  • p120(CAS)
  • p120(CTN)
  • p120cas
  • p120ctn

Background

The alpha, beta, delta, and gamma -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. alpha-catenin, a 102 kDa protein, interacts with E-cadherin associated protein, and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. The 92 kDa beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin also complexes with the tumor suppressor protein APC. delta-catenin interacts with Presenilin 1 and is expressed in the brain. The gene encoding delta-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding delta-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. gamma-catenin, also known as plakoglobin, is an 80-88 kDa protein that binds alpha-catenin and N-cadherin. In addition, the transmembrane phosphatase PTPm associates with catenin/cadherin complexes and may regulate complex signaling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CTNND1