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OX40/TNFRSF4 Antibody (OX-40) Summary
Phytohemagglutinin (PHA) activated Rat Lymph Node Cells
Cell Membrane. Type I membrane protein.
NB100-65293 recognizes the OX40 antigen which is present on activated T lymphocytes that also express CD4 (1). The antigen is a glycoprotein of approximately 50kD molecular weight which is related in sequence to the low affinity Nerve Growth Factor Receptor (2). Clone OX-40 is not mitogenic, but does enhance some T cell responses (1).
Protein G purified
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tumor necrosis factor receptor superfamily member 4
tumor necrosis factor receptor superfamily, member 4
The OX40 receptor is also known as CD134, ACT35, and tumour necrosis factor receptor superfamily member 4. This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX40 receptor binds to the OX40 ligand to provide a co-stimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, imply that these interactions are important in the pathogenesis of some autoimmune diseases.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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