OX40/TNFRSF4 Antibody (OX-40)

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Flow Cytometry: OX40/TNFRSF4 Antibody (OX-40) [NB100-65293] - Analysis using the FITC conjugate of NB100-65293. Staining of stimulated rat spleen cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-65293
    • Availability
      Product Discontinued

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OX40/TNFRSF4 Antibody (OX-40) Summary

Immunogen
Phytohemagglutinin (PHA) activated Rat Lymph Node Cells
Localization
Cell Membrane. Type I membrane protein.
Specificity
NB100-65293 recognizes the OX40 antigen which is present on activated T lymphocytes that also express CD4 (1). The antigen is a glycoprotein of approximately 50kD molecular weight which is related in sequence to the low affinity Nerve Growth Factor Receptor (2). Clone OX-40 is not mitogenic, but does enhance some T cell responses (1).
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF4
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10 - 1:50
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
Publications
Read Publication using
NB100-65293 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for OX40/TNFRSF4 Antibody (OX-40)

  • ACT-135
  • ACT35 antigen
  • ACT35ATC35 antigen
  • CD134 antigen
  • CD134
  • Ly-70
  • OX40 cell surface antigen
  • OX40 homologue
  • OX40
  • OX40L receptor
  • OX40lymphoid activation antigene ACT35
  • TAX transcriptionally-activated glycoprotein 1 receptor
  • tax-transcriptionally activated glycoprotein 1 receptor
  • TNFRSF4
  • tumor necrosis factor receptor superfamily member 4
  • tumor necrosis factor receptor superfamily, member 4
  • Txgp1
  • TXGP1L
  • TXGP1LOX40 antigen

Background

The OX40 receptor is also known as CD134, ACT35, and tumour necrosis factor receptor superfamily member 4. This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX40 receptor binds to the OX40 ligand to provide a co-stimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, imply that these interactions are important in the pathogenesis of some autoimmune diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for OX40/TNFRSF4 Antibody (NB100-65293)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: FLOW.


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FLOW
(1)
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Diseases for OX40/TNFRSF4 Antibody (NB100-65293)

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PTMs for OX40/TNFRSF4 Antibody (NB100-65293)

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Bioinformatics

Gene Symbol TNFRSF4
Entrez