OTUD5 Antibody

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

OTUD5 Antibody Summary

Immunogen
Peptide with sequence C-RQVRGPSQPRKAS corresponding to internal region according to NP_060072.1.
Epitope
C terminus
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
OTUD5
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:64000
Application Notes
WB: Preliminary experiments gave an approx. 80 kDa band in lysates of Jurkat and MOLT4 after 0.2 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 60.6 kDa band according to NP_060072.1. The 80 kDa band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-20909.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for OTUD5 Antibody

  • Deubiquitinating enzyme A
  • DKFZp761A052
  • DUBAdeubiquinating enzyme A
  • EC 3.4.19.12
  • MGC104871
  • OTU domain containing 5
  • OTU domain-containing protein 5

Background

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for OTUD5 Antibody (NBP1-20909)(1)


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Secondary Antibodies

 

Isotype Controls

Additional OTUD5 Products

OTUD5 NBP1-20909

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Bioinformatics

Gene Symbol OTUD5
Entrez
Uniprot