OSMR Antibody (AN-V2) [PE]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
AN-V2
Clonality
Monoclonal
Host
Mouse

Order Details

OSMR Antibody (AN-V2) [PE] Summary

Immunogen
The immunogen for this antibody is OSMR.
Specificity
The AN-V2 monoclonal antibody recognizes the type II (beta) OSM receptor.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
OSMR
Purity
Protein A or G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Conjugate
PE
Format
PE (A=488, E=575)
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
This AN-V2 antibody has been pre-titrated and tested by flow cytometric analysis of the A375 cell line. This can be used at 5 uL (0.5 ug) per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Reactivity Notes

Human

Alternate Names for OSMR Antibody (AN-V2) [PE]

  • IL-31 receptor subunit beta
  • IL-31R subunit beta
  • IL-31RB
  • IL-31R-beta
  • Interleukin-31 receptor subunit beta
  • MGC150627
  • MGC75127
  • oncostatin M receptor
  • oncostatin-M specific receptor beta subunit
  • oncostatin-M-specific receptor subunit beta
  • OSMRBMGC150626

Background

This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor. OSM, which belongs to the interleukin-6 cytokine family, is produced by T cells, activated monocytes, and dendritic cells. In humans, OSM can bind two unique receptor complexes. The type I OSM receptor is composed of the LIFR associated with gp130, and recognizes both LIF and OSM. The type II OSM receptor, which consists of gp130 and the OSMR subunit, specifically binds the cytokine, leading to activation of the JAK/STAT signaling pathway. Reports have also indicated a soluble form of the OSM receptor, which this antibody also recognizes. The OSM receptor is expressed in the bone marrow, endothelium, liver, lung, and numerous tumor cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

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Blogs on OSMR

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol OSMR

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