Notch-1 Antibody


Western Blot: Notch-1 Antibody [NBP1-51487] - Analysis of extracts from NIH/3T3 cells.
Immunohistochemistry-Paraffin: Notch-1 Antibody [NBP1-51487] - Human brain tissue.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IHC-P
1.0 mg/ml

Order Details

Notch-1 Antibody Summary

The immunogen for this antibody was a synthetic Cleaved-Notch 1 (V1754) peptide.
Cleaved-Notch 1 (V1754) pAb detects endogenous levels of Cleaved-Notch 1 protein.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, approx. pH 7.2.
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


Application Notes
Western blot (WB) analysis of Cleaved-Notch 1 (V1754) pAb in extracts from NIH/3T3 cellsImmunohistochemistry (IHC) analyzes of Cleaved-Notch 1 (V1754) pAb in paraffin-embedded human brain tissue.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
110 kDa

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Alternate Names for Notch-1 Antibody

  • EC
  • EC
  • hN1
  • Notch (Drosophila) homolog 1 (translocation-associated)
  • notch 1Notch homolog 1, translocation-associated (Drosophila)
  • Notch homolog 1, translocation-associated
  • Notch1
  • TAN1
  • TAN1neurogenic locus notch homolog protein 1
  • Translocation-associated notch protein TAN-1


Notch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain. Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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Blogs on Notch-1.

Notch1 - A multifunctional transmembrane receptor
Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol NOTCH1

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