Notch-1 Antibody (4C9)

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Western Blot: Notch1 Antibody (4C9) [NBP1-48288] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Notch1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates ...read more
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] Staining of paraffin-embedded pancreas tissue using anti-Notch1mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-Notch1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-Notch1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded breast tissue using anti-Notch1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded Carcinoma of kidney tissue using anti-Notch1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded Carcinoma of lung tissue using anti-Notch1mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded Carcinoma of thyroid tissue using anti-Notch1mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded endometrium tissue using anti-Notch1mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded Kidney tissue using anti-Notch1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Notch1 Antibody (4C9) [NBP1-48288] - Staining of paraffin-embedded liver tissue using anti-Notch1mouse monoclonal antibody.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-48288
    • Availability
      Product Discontinued

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Notch-1 Antibody (4C9) Summary

Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1
Specificity
This antibody is specific for Homo sapiens Notch homolog 1, translocation-associated (Drosophila) (NOTCH1).
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
NOTCH1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Notch-1 Antibody (4C9)

  • EC 2.1.2.11
  • EC 3.4.21.68
  • hN1
  • Notch (Drosophila) homolog 1 (translocation-associated)
  • notch 1Notch homolog 1, translocation-associated (Drosophila)
  • Notch homolog 1, translocation-associated
  • Notch1
  • Notch-1
  • TAN1
  • TAN1neurogenic locus notch homolog protein 1
  • Translocation-associated notch protein TAN-1

Background

Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Diseases for Notch-1 Antibody (NBP1-48288)

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Research Areas for Notch-1 Antibody (NBP1-48288)

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Blogs on Notch-1.

Notch1 - A multifunctional transmembrane receptor
Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process...  Read full blog post.

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Bioinformatics

Gene Symbol NOTCH1
Entrez