Nogo Antibody

Images

 
Western Blot: Nogo Antibody [NBP1-51208] - analysis of Nogo A (E499) pAb in extracts from COLO205 cells
Immunohistochemistry-Paraffin: Nogo Antibody [NBP1-51208] - analyzes of Nogo A (E499) pAb in paraffin-embedded human skeletal muscle tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51208
    • Availability
      Product Discontinued

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Nogo Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 467-517 of Human Nogo A.
Specificity
Nogo A (E499) pAb detects endogenous levels of Nogo A protein.
Clonality
Polyclonal
Host
Rabbit
Gene
RTN4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Nogo A (E499) pAb in extracts from COLO205 cellsImmunohistochemistry (IHC) analyzes of Nogo A (E499) pAb in paraffin-embedded human skeletal muscle tissue.
Theoretical MW
130 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Nogo Antibody

  • ASY
  • foocen
  • Human NogoA
  • KIAA0886
  • My043 protein
  • Nbla00271
  • Nbla10545
  • neurite growth inhibitor 220
  • Neurite outgrowth inhibitor
  • Neuroendocrine-specific protein C homolog
  • Neuroendocrine-specific protein
  • NI220/250
  • Nogo protein
  • NOGO-A
  • Nogo-B
  • NOGOC
  • Nogo-C
  • NOGORTN4-B1
  • NSP
  • NSP-CL
  • reticulon 4
  • reticulon 5
  • reticulon-4
  • reticulon-5
  • RTN4-A
  • RTN4-B2
  • RTN4-C
  • RTN-x

Background

CNS white matter is selectively inhibitory for axonal out-growth. Nogo (also designated NI250 and Reticulon 4-A) is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Other members of the Reticulon protein family do not inhibit axon xtension and are thought to have a role in ER function. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo A, Nogo B and Nogo C.Nogo A and Nogo C have a molecular mass of 200-250 kDa and 22 kDa, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Nogo Antibody (NBP1-51208)

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Diseases for Nogo Antibody (NBP1-51208)

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Pathways for Nogo Antibody (NBP1-51208)

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Research Areas for Nogo Antibody (NBP1-51208)

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Blogs on Nogo.

Nogo: A Promising Target for New Gene Therapies
Nogo is a neurite outgrowth inhibitor protein that plays an important role during central nervous system (CNS) development as well as in endoplasmic reticulum signaling regulation. Studies using Nogo antibodies have revealed Nogo proteins regulate...  Read full blog post.

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Bioinformatics

Gene Symbol RTN4