Noggin Recombinant Protein Summary
A recombinant protein corresponding to 206 amino acids of Human Noggin
Source: E. coli
Amino Acid Sequence: The amino acid sequence of this product is not available.
|Details of Functionality
Determined by its ability to inhibit 5 ng/ml of BMP-4-induced alkaline phosphatase production by ATDC chondrogenic cells. The expected EDSO for the effect is 0.05-0.08ug/ml of Noggin
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Sterile filtered and with no additives.
Reconstitute with water to a final concentration of 0.1 - 1.0 mg/ml.
After reconstituted, dilute further with other aqueous solutions.
Alternate Names for Noggin Recombinant Protein
- symphalangism 1 (proximal)
- synostoses (multiple) syndrome 1
Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-Beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 23.1 kDa non-disulfide-linked homodimer consisting of a total of 206 amino acid residues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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Bioinformatics Tool for Noggin Protein (NBP1-99735)
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