Noggin Antibody (4C12)

Images

 
Western Blot: Noggin Antibody (4C12) [NBP1-47880] Analysis of extracts (35ug) from 9 different cell lines by using anti-Noggin monoclonal antibody.
Immunocytochemistry/ Immunofluorescence: Noggin Antibody (4C12) [NBP1-47880] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY Noggin.
Immunohistochemistry-Paraffin: Noggin Antibody (4C12) [NBP1-47880] - Staining of paraffin-embedded Human Ovary tissue using anti-Noggin mouse monoclonal antibody.
Western Blot: Noggin Antibody (4C12) [NBP1-47880] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Noggin (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell ...read more
Western Blot: Noggin Antibody (4C12) [NBP1-47880] - Noggingin antibody (4C12) at 1:2000 + Recombinant human Noggingin.
Immunocytochemistry/ Immunofluorescence: Noggin Antibody (4C12) [NBP1-47880] - Immunofluorescent staining of A549 cells using anti-Noggin mouse monoclonal antibody.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-47880
    • Availability
      Product Discontinued

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Noggin Antibody (4C12) Summary

Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 28-232 of human noggin
Specificity
This antibody is specific for Homo sapiens noggin (NOG).
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
NOG
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000-2000
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Noggin Antibody (4C12)

  • NOG
  • Noggin
  • SYM1
  • symphalangism 1 (proximal)
  • synostoses (multiple) syndrome 1
  • SYNS1

Background

Noggin is a secreted polypeptide which binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, it may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. The results of the mouse knockout of the ortholog suggest that noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Diseases for Noggin Antibody (NBP1-47880)

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Blogs on Noggin.

Five Funny Protein Names: Infographic
Some proteins have the strangest names. Check out our list for some of the funniest ones and learn more about each protein including their function, gene symbol, molecular weight and family.Novus Biologicals offers reagents for each target:Merli...  Read full blog post.

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Bioinformatics

Gene Symbol NOG
Entrez