NGF R/TNFRSF16/p75NTR Antibody



Product Details

Product Discontinued
View other related NGF R/TNFRSF16/p75NTR Primary Antibodies

Order Details

    • Catalog Number
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

NGF R/TNFRSF16/p75NTR Antibody Summary

A synthetic peptide as a part of human, rat p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR) conjugated to an immunogenic carrier protein was used as the immunogen.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
No Preservative
This product is unpurified. The exact concentration of antibody is not quantifiable.
Reconstitution Instructions
Reconstitute with 0.1 ml sterilized water to desired concentration.

Reactivity Notes

Human and Rat.


Nerve Growth Factor Receptor, also termed NGFR p75, p75NTR, or CD271 is the low affinity NGFR (LNGFR) which binds NGF and other neurotrophins including BDNF, NT3, NT4/5 with similar, low affinity. NGFR p75 is a 75kD transmembrane glycoprotein (399 a.a.) consisting of an extracellular domain (222 a.a.) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 a.a.), and a cytoplasmic domain (155 a.a.). NGFR p75 is mainly expressed in Schwann cells and neurons and in a variety of non neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. The signal transduction mechanisms and components leading to NGFR p75 multiple signals are complex and not well understood. In contrast to other members of the neurotrophin receptors family (TrkA, TrkB and TrkC tyrosine kinases), NGFR p75 lacks intrinsic catalytic activity. It has been suggested that NGFR p75 interacts with TrkA to form high affinity binding sites and to modulate TrkA signaling. NGFR p75 belongs to the TNF receptor superfamily which includes TNFR, CD40 and Fas. These receptors all have an intracellular death domain and can couple to parallel signaling pathways leading to apoptotic cell death or activation of the transcription factor NF kappaB. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, ICC
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP, S-ELISA
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu
Applications: WB, ELISA, IHC, IHC-P, PLA, S-ELISA
Species: Hu
Applications: Flow, IHC, Neut
Species: Hu
Applications: WB, Flow, IHC, Neut
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Species: Hu, Mu, Rt, Av, Ch, GP, Pm
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-WhMt
Species: Mu, Rt
Applications: WB, Simple Western, IHC, Block
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Rt
Applications: WB, IHC, IHC-Fr, IHC-P

Publications for p75NTR/NGF Receptor Antibody (NB100-91264) (0)

There are no publications for p75NTR/NGF Receptor Antibody (NB100-91264).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for p75NTR/NGF Receptor Antibody (NB100-91264) (0)

There are no reviews for p75NTR/NGF Receptor Antibody (NB100-91264). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

FAQs for p75NTR/NGF Receptor Antibody (NB100-91264) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional NGF R/TNFRSF16/p75NTR Antibody Products

Related Products by Gene

Bioinformatics Tool for p75NTR/NGF Receptor Antibody (NB100-91264)

Discover related pathways, diseases and genes to p75NTR/NGF Receptor Antibody (NB100-91264). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for p75NTR/NGF Receptor Antibody (NB100-91264)

Discover more about diseases related to p75NTR/NGF Receptor Antibody (NB100-91264).

Pathways for p75NTR/NGF Receptor Antibody (NB100-91264)

View related products by pathway.

PTMs for p75NTR/NGF Receptor Antibody (NB100-91264)

Learn more about PTMs related to p75NTR/NGF Receptor Antibody (NB100-91264).

Blogs on NGF R/TNFRSF16/p75NTR

There are no specific blogs for NGF R/TNFRSF16/p75NTR, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol NGFR

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB100-91264 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.