NGF R/TNFRSF16/p75NTR Antibody (2F1C2)

Images

 
Western Blot: NGF R/TNFRSF16/p75NTR Antibody (2F1C2) [NBP1-51590] - Analysis using p75NTR/NGF Receptor mouse mAb against NGFR-hIgGFc transfected HEK293 cell lysate.
Immunocytochemistry/ Immunofluorescence: NGF R/TNFRSF16/p75NTR Antibody (2F1C2) [NBP1-51590] - Analysis of EC cells using p75NTR/NGF Receptor mouse mAb (green). Red: Actin filaments have been labeled with DY-554 ...read more
Flow Cytometry: NGF R/TNFRSF16/p75NTR Antibody (2F1C2) [NBP1-51590] - Analysis of EC cells using p75NTR/NGF Receptor mouse mAb (green) and negative control (purple).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF
Clone
2F1C2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

NGF R/TNFRSF16/p75NTR Antibody (2F1C2) Summary

Immunogen
Purified recombinant fragment of human p75NTR/NGF Receptor expressed in E. coli. [UniProt# P08138]
Localization
Membrane; Single-pass type I membrane protein.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
NGFR
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:10000
  • Flow Cytometry 1:200-1:400
  • Immunocytochemistry/Immunofluorescence 1:200-1:1000
Application Notes
This p75NTR/NGF Receptor (2F1C2) antibody is useful in Western Blot, ELISA, Immunocytochemistry/Immunofluorescence and Flow Cytometry. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.03% Sodium Azide
Purity
Unpurified

Alternate Names for NGF R/TNFRSF16/p75NTR Antibody (2F1C2)

  • CD271 antigen
  • CD271
  • Gp80-LNGFR
  • member 16
  • nerve growth factor receptor
  • NGF R
  • NGF receptor
  • NGFR
  • p75 ICD
  • p75 NTR
  • TNFRSF16
  • TNFRSF16nerve growth factor receptor (TNFR superfamily, member 16)
  • tumor necrosis factor receptor superfamily member 16

Background

p75NTR/NGF Receptor, also known as Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. p75NTR/NGF Receptor plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of p75NTR/NGF Receptor by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to p75NTR/NGF Receptor activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICC/IF Video Protocol

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Bioinformatics

Gene Symbol NGFR
Entrez
Uniprot