Neurotensin Receptor 1 Antibody

Images

 
Immunohistochemistry-Paraffin: Neurotensin Receptor 1 Antibody [NLS935] - Human Ovary, Carcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: Neurotensin Receptor 1 Antibody [NLS935] - Analysis of anti-NTSR1 / NTR antibody with brain, neurons and glia at 6 ug/ml.
Immunohistochemistry-Paraffin: Neurotensin Receptor 1 Antibody [NLS935] - Analysis of anti-NTSR1 / NTR antibody with human adrenal, pheochromocytoma.
Immunohistochemistry-Paraffin: Neurotensin Receptor 1 Antibody [NLS935] - Human Lung, Adenocarcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Details

Summary
Reactivity Hu, Mk, PmSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Neurotensin Receptor 1 Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human NTSR1.
Epitope
N-terminal extracellular domain of human
Specificity
Human NTSR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NTSR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 3 - 16 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Elephant (94%), Marmoset (89%), Hamster (83%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Neurotensin Receptor 1 Antibody

  • High-affinity levocabastine-insensitive neurotensin receptor
  • neurotensin receptor 1 (high affinity)
  • neurotensin receptor type 1
  • NTR
  • NTR1
  • NT-R-1
  • NTRH
  • NTRR

Background

NTR1, a Neurotensin Receptor, activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems. It mediates the functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Neurotensin Receptor 1 expression is enhanced in pancreatic cancer and in chronic pancreatitis (Wang et al, 2000). Two differentially glycosylated forms of the NT1 receptor have been identified in rats, a 54-kDa form that is expressed from birth to adulthood, and a 52-kDa form only detected at 10 and 15 days postnatal. NTR1 has been reported in brain, pancreas, and small intestine. ESTs have been isolated from brain and colon libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol NTSR1
Entrez