Neprilysin/CD10 Antibody (SN5c/L4-1A1) [PE]

Images

 
Flow Cytometry: Neprilysin/CD10 Antibody (SN5c/L4-1A1) [PE] [NBP1-43891] - Staining of normal human peripheral blood cells with Mouse IgG1 k Isotype Control PE (blue histogram) or Anti-Human CD10 PE (purple histogram).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
SN5c/L4-1A1
Clonality
Monoclonal
Host
Mouse

Order Details

Neprilysin/CD10 Antibody (SN5c/L4-1A1) [PE] Summary

Immunogen
Native purified MME from membrane preparation of human B-lineage leukemia cells.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MME
Purity
Protein A or G purified
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Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Conjugate
PE
Format
PE (A=488, E=575)
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
This antibody is useful for Immunoprecipitation, Flow cytometry / FACS analysis, Immunohistochemistry-Frozen

Reactivity Notes

Human.

Alternate Names for Neprilysin/CD10 Antibody (SN5c/L4-1A1) [PE]

  • Atriopeptidase
  • CALLA
  • CALLAmembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)
  • CD10 antigen
  • CD10
  • CD10)
  • CD10membrane metallo-endopeptidase variant 1
  • Common acute lymphocytic leukemia antigen
  • DKFZp686O16152
  • EC 3.4.24
  • EC 3.4.24.11
  • Enkephalinase
  • EPN
  • Leu-19
  • membrane metallo-endopeptidase variant 2
  • membrane metallo-endopeptidase
  • MGC126681
  • MGC126707
  • MME
  • NEPmembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA
  • neprilysin
  • Neprilysin/CD10
  • Neutral Endopeptidase 24.11
  • Neutral endopeptidase
  • NKH1
  • SFE
  • Skin fibroblast elastase

Background

The SN5c monoclonal antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALLs). Subsequently, CD10 was shown to be the same molecule as neutral endopeptidase (NEP), or KII-NA. CD10 is a Zn2+-dependent metallopeptidase acting on substrates such as endothelin, glucagon, gastrin, neurotensin and bradykinin. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and its expression has been reported on mature germinal center B cells. CD10 expression is also found on normal donor granulocytes and bone marrow stromal cells. Most likely, CB-CALLA and SN5c see different epitopes due to their ability to co-stain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MME
Entrez
Uniprot

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