Cross-reacts with Human. Rat reactivity reported in scientific literature (PMID: 25172893) Not yet tested in other species.
Alternate Names for NEIL1 Antibody
DNA-(apurinic or apyrimidinic site) lyase Neil1
endonuclease 8-like 1
Endonuclease VIII-like 1
FPG1DNA glycosylase/AP lyase Neil1
nei endonuclease VIII-like 1 (E. coli)
Nei homolog 1
Nei-like protein 1
Prokaryotes and lower eukaryotes possess activities that remove the plethora of oxidative DNA base damages produced during normal oxidative metabolism and which have been associated with cancer and aging. The availability of the human genome sequence has precipitated identification of human homologs of Escherichia coli Nei. Human NEIL1 is a DNA glycosylase, that phylogenetically belongs to the Fpg/Nei family, primarily found in the bacterial kingdom and is functionally homologous to bacterial Nei. Thymine glycol, a potentially lethal DNA lesion produced by reactive oxygen species, can be removed by DNA glycosylases. The NEIL1 gene is located on the long arm of chromosome 15 that is frequently deleted in human cancers.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.