Nbs1 Antibody

Images

 
Western Blot: NBS1 Antibody [NB100-60653] - Detection of Human NBS1 on HeLa whole cell lysate using NB100-60653. NBS1 was also immunoprecipitated by rabbit anti-NBS1 antibodies NB100-60654 and another.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-60653
    • Availability
      Product Discontinued

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Nbs1 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 425 and 475 of human Nibrin using the numbering given in entry NP_002476.2 (GeneID 4683).
Clonality
Polyclonal
Host
Rabbit
Gene
NBN
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 2-5 ug/mg lysate
Positive Control
Nbs1 Lysate (NBL1-13497)

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Nbs1 Antibody

  • ATV
  • AT-V1
  • AT-V2
  • Cell cycle regulatory protein p95
  • FLJ10155
  • MGC87362
  • NBN
  • Nbs1
  • NBS1P95
  • NBSNijmegen breakage syndrome protein 1
  • Nibrin
  • Nijmegen breakage syndrome 1 (nibrin)
  • p95 protein of the MRE11/RAD50 complex
  • p95

Background

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Nbs1 Antibody (NB100-60653) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional Nbs1 Products

Bioinformatics Tool for Nbs1 Antibody (NB100-60653)

Discover related pathways, diseases and genes to Nbs1 Antibody (NB100-60653). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Nbs1 Antibody (NB100-60653)

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Pathways for Nbs1 Antibody (NB100-60653)

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PTMs for Nbs1 Antibody (NB100-60653)

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Research Areas for Nbs1 Antibody (NB100-60653)

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Blogs on Nbs1.

The MRE11 Complex and DNA Damage Response
The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra...  Read full blog post.

NBS1: The DNA Repair Trigger
NBS1 (Nijmegen breakage syndrome protein 1) is a component of the MRN complex (Mre11-Rad50-Nbs1) that plays important role in detecting DNA double strand breaks (DSBs) and triggering the downstream cascade. DSBs can be caused by ionizing radiation, ch...  Read full blog post.

NBS1: DNA Repair Trigger
NBS1 (Nijmegen breakage syndrome protein 1) is a component of the MRN complex (Mre11-Rad50-Nbs1) that plays important role in detecting DNA double strand breaks (DSBs) and triggering the downstream cascade. DSBs can be caused by ionizing radiation, ch...  Read full blog post.

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Bioinformatics

Gene Symbol NBN
Entrez
Uniprot