Nav1.5 Antibody (4G8.1G7)

Images

 
Immunocytochemistry/ Immunofluorescence: Nav1.5 Antibody (4G8-1G7) [NB110-61010] - Figure A: Plasma membrane localisation of Nav1.5 identified by 4G8:1G7 detected by anti-mouse Alexa Fluor-488 conjugated antibody; ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC, IP, RIA, CyTOF-ready
Clone
4G8.1G7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Nav1.5 Antibody (4G8.1G7) Summary

Immunogen
Retinoblastoma tissue membrane fraction
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SCN5A
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100 - 1:2000
  • ELISA 1:100 - 1:2000
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Radioimmunoassay 1:100 - 1:2000
  • CyTOF-ready
Application Notes
In the mouse brain, 3 main isoforms have been described of 180,140 and 120 kDa MW. A Western blot of 2 year old pediatric brain revealed bands of 180,140 and 120 kDa (weakly) with ERIC-1.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Notes

Positive control(s): Neuroblastome.

Alternate Names for Nav1.5 Antibody (4G8.1G7)

  • cardiac sodium channel alpha subunit
  • cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
  • CDCD2VF1
  • HB1sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
  • HB2
  • HBBD
  • HH1CMD1E
  • ICCD
  • IVF
  • LQT3SSS1CMPD2
  • Nav1.5
  • PFHB1
  • Sodium channel protein cardiac muscle subunit alpha
  • sodium channel protein type 5 subunit alpha
  • sodium channel protein type V alpha subunit
  • Sodium channel protein type V subunit alpha
  • sodium channel, voltage-gated, type V, alpha subunit
  • Voltage-gated sodium channel subunit alpha Nav1.5

Background

Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signaling in nerves and muscles. Expression is also detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatory beta-subunit. Expression has been detected in a number of tumor cell lines and has been implicated in the metastatic behavior of breast and prostate cancer cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Nav1.5 Antibody (NB110-61010). (Showing 1 - 1 of 1 FAQ).

  1. The customer has requested to see any western blot data that you have available for this antibody.
    • For our product NB110-61010, we have validated the western blot application by customer review. Unfortunately, the customer review did not come with an image. As this is a listed application on our webpage, we will fully guarantee western blot detection of human Nav1.5 with this product. Here is a link of our guarantee for your customer's reference. I am sorry that we did not have the data requested by your customer. Please let me know if they have any additional questions.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB110-61010AF405
Alexa Fluor 488 Labeled NB110-61010AF488
Alexa Fluor 647 Labeled NB110-61010AF647
Alexa Fluor 700 Labeled NB110-61010AF700
Allophycocyanin Labeled NB110-61010APC
DyLight 350 Labeled NB110-61010UV
DyLight 405 Labeled NB110-61010V
DyLight 488 Labeled NB110-61010G
DyLight 680 Labeled NB110-61010FR
DyLight 755 Labeled NB110-61010IR
PE Labeled NB110-61010PE
PerCP Labeled NB110-61010PCP

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Bioinformatics

Gene Symbol SCN5A
Entrez