N-Cadherin Antibody (8C11) [Biotin] (NBP2-00232)

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Flow Cytometry: N-Cadherin Antibody (8C11) [Biotin] [NBP2-00232] - Staining of the HeLa cell line with 0.25 ug of Mouse IgG1 K Isotype Control Biotin (blue histogram) or 0.25 ug of Anti-Human CD325 (N-Cadherin) Biotin ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-00232
    • Availability
      Product Discontinued

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N-Cadherin Antibody (8C11) [Biotin] Summary

Immunogen
Bacterial fusion protein corresponding to the extracellular domain of N-cadherin.
Marker
Mesenchymal Cells Marker
Specificity
Detects a band at approximately 100kDa
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CDH2
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5 ug/10^6 cells in 100 ul
Application Notes
IF: Use at a concentration of 10 ug/ml. IP: Use at an assay dependent dilution. WB: Use at a concentration of 1 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Readout System

Reactivity Notes

Avian reactivity reported in scientific literature (PMID: 20197094).

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for N-Cadherin Antibody (8C11) [Biotin]

  • cadherin 2, N-cadherin (neuronal)
  • cadherin 2, type 1, N-cadherin (neuronal)
  • Cadherin-2
  • CD325 antigen
  • CD325
  • CDH2
  • CDHNcalcium-dependent adhesion protein, neuronal
  • CDw325
  • NCadherin
  • N-Cadherin
  • NCADN-cadherin 1
  • Neural cadherin
  • neural-cadherin

Background

The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130 kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CDH2
Entrez