MVP Antibody (MVP-37)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51766
    • Availability
      Product Discontinued

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MVP Antibody (MVP-37) Summary

Immunogen
The antibody reacts with an internal epitope of MVP/LRP (p110).
Specificity
MVP-37 reacts with an internal epitope of MVP/LRP (p110), which is strongly overexpressed in various human non-P-glycoprotein MDR tumor cell lines, accordingly to an increase in the number of vault particles.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
MVP
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
MVP-37 has potential value for detection of MVP/LRP-associated non-Pgp MDR in human tumor samples. Immunohistochemistry: use approx. 1:20-50 dilution on 4% paraformaldehyde fixed cytospin preparations or frozen tissue sections (apply the following pretrea

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Serum - free culture supernatant with 0.7% BSA
Preservative
0.1% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for MVP Antibody (MVP-37)

  • LRPVAULT1
  • Lung resistance-related protein
  • major vault protein

Background

This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MVP Antibody (NBP1-51766) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for MVP Antibody (NBP1-51766). (Showing 1 - 1 of 1 FAQ).

  1. Are there any MVP antibodies that will recognize mouse and can be used for immunofluorescence?
    • At this time we do not have an MVP antibody that will recognize mouse and has been used for immunofluorescence. If you would like to try an antibody in an untested species or application you would qualify for our Innovator's Reward program. Through this program if you complete an online review with image, detailing your positive or negative results we will send you a discount voucher for 100% of the purchase price of the reviewed product.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

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