MVP Antibody (LMR5)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51765
    • Availability
      Product Discontinued

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MVP Antibody (LMR5) Summary

Immunogen
The antibody reacts with Human MVP.
Specificity
LMR5 reacts with an internal epitope of the LRP/Major Vault Protein (P110), which is stronly overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Gene
MVP
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
LMR5 has potential value for detection of LRP/MVP-associated non-Pgp MDR in human tumor samples. The antibody can be diluted 1:20 for immuno-histochemical staining of frozen sections, air-dried or acetone fixed cells, paraffin embedded tissue sections and

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
1.0% BSA
Preservative
0.1% Sodium Azide
Purity
Protein A or G purified

Alternate Names for MVP Antibody (LMR5)

  • LRPVAULT1
  • Lung resistance-related protein
  • major vault protein

Background

This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for MVP Antibody (NBP1-51765). (Showing 1 - 1 of 1 FAQ).

  1. Are there any MVP antibodies that will recognize mouse and can be used for immunofluorescence?
    • At this time we do not have an MVP antibody that will recognize mouse and has been used for immunofluorescence. If you would like to try an antibody in an untested species or application you would qualify for our Innovator's Reward program. Through this program if you complete an online review with image, detailing your positive or negative results we will send you a discount voucher for 100% of the purchase price of the reviewed product.

Secondary Antibodies

 

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