MTA2 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-66251
    • Availability
      Product Discontinued

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MTA2 Antibody Summary

Immunogen
Peptide with the sequence C-LKVKPTLIAVRP Sequence according to the Entrez Gene accession number NP_004730
Specificity
This is a NuRD complex subunit that may regulate histone deacetylase core complex enzymatic activity.
Clonality
Polyclonal
Host
Goat
Gene
MTA2
Purity
IgG purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
TBS
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
IgG purified

Alternate Names for MTA2 Antibody

  • DKFZp686F2281
  • metastasis associated 1 family, member 2
  • metastasis -associated gene 1-like 1
  • metastasis associated gene family, member 2
  • Metastasis-associated 1-like 1
  • metastasis-associated protein 2
  • metastasis-associated protein MTA2
  • MTA1-L1 protein
  • MTA1L1MTA1-L1
  • p53 target protein in deacetylase complex
  • PID

Background

The p53 tumor suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53 dependent transcriptional activation and modulates p53 mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MTA2
Entrez
Uniprot