MRP2 Antibody (M2II-12)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42350
    • Availability
      Product Discontinued

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MRP2 Antibody (M2II-12) Summary

Immunogen
The antibody reacts with the MRP2 antigen.
Specificity
M2II-12 reacts with an internal epitope of cMOAT/MRP2, a 190-200 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2II-12 was raised against a bacterial fusion protein of cMOAB/M­RP2, containing amino acids 860-950 of the protein. M2II-12 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
ABCC2
Purity
Tissue culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
M2II-12 has potential value for detection of MRP2-mediated drug-resistance in human tumor samples. Immunocytochemistry: use 1:20-50 dil. on acetone fixed cytospin preparations. For immunohistochemistry: M2II-12 (use 1:20) on acetone fixed frozen sections

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.1% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for MRP2 Antibody (M2II-12)

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Canalicular multidrug resistance protein
  • canalicular multispecific organic anion transporter 1
  • CMOAT1
  • CMOATABC30
  • cMRP
  • DJS
  • KIAA1010
  • MRP2ATP-binding cassette sub-family C member 2
  • Multidrug resistance-associated protein 2

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ABCC2