MRP1 Antibody (MRPr1)

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Product Details

Summary
Product Discontinued
View other related MRP1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-42325
    • Availability
      Product Discontinued

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MRP1 Antibody (MRPr1) Summary

Immunogen
The antibody reacts with the MRP1 antigen.
Specificity
MRPr1 reacts with an epitope of MRP, a 180-195 kD transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. MRPr1 was raised against a bacterial fusion protein of MRP, containing a segment of 168 amino acids in the amino-proximal half of the protein. MRPr1 does not cross-react with the human MDR1 and MDR3 gene products (Flens et al. 1994).
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
ABCC1
Purity
Tissue culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
MRPr1 has potential value for detection of MRP-related non-Pgp MDR in human tumor samples. Working dilutions. Flow cytometry: at least 1:20-1:50. Western blotting: at least 1:20-1:50. Immunocytochemistry: aceton fixed cell preparation at least 1:20-50. IFor use of paraffin embedded sections a 0.01M citrate pretreatment (10 min. at 100°C) may increase the performance of this antibody. In Flow cytometry fixate cells in 10% (v/v) Lysing solution followed by primairy antibody and anti-Rat-FITC. In developing
Publications
Read Publication using NBP1-42325.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.1% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for MRP1 Antibody (MRPr1)

  • ABC29
  • ABCC
  • ABCC1
  • ATP-binding cassette sub-family C member 1
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1
  • EC 3.6.3
  • EC 3.6.3.44
  • GS-X
  • Leukotriene C(4) transporter
  • LTC4 transporter
  • MRP1
  • MRP1DKFZp781G125
  • MRPDKFZp686N04233
  • multidrug resistance associated protein 1
  • multidrug resistance protein
  • multidrug resistance-associated protein 1
  • multiple drug resistance protein 1
  • multiple drug resistance-associated protein

Background

The MRP molecule, an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein, is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumours. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MRP1 Antibody (NBP1-42325)(1)

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Secondary Antibodies

 

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Additional MRP1 Products

MRP1 NBP1-42325

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Diseases for MRP1 Antibody (NBP1-42325)

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Blogs on MRP1.

ABC Membrane transporters and the role of MRP1 in drug resistance
ATP-binding cassette (ABC) transporters, alongside ion channels and aquaporins, are ubiquitous membrane-bound proteins that move substrates across extra and intra cellular membranes.  Multidrug resistance-associated protein 1 (MRP1) is a member o...  Read full blog post.

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Bioinformatics

Gene Symbol ABCC1
Entrez