Western Blot: Mre11 Antibody [NB100-276] - Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Mre11a antibody used for WB at 0.4 ug/ml. ...read more
Immunohistochemistry: Mre11 Antibody [NB100-276] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- Mre11 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Western Blot: Mre11 Antibody [NB100-276] - Whole cell lysate (5, 15 and 50 ug) from HeLa cells. Antibody used at 0.1 ug/ml.
Immunohistochemistry-Paraffin: Mre11 Antibody [NB100-276] - FFPE section of human basal cell carcinoma. Affinity purified rabbit anti-Mre11 used at a dilution of 1:250. Detection: DAB staining using ...read more
Proximity Ligation Assay: Mre11 Antibody [NB100-276] - Secondary-conjugate Duolink II PLA in Hela cells. goat anti-human ATM (NB100-271) and rabbit anti-human MRE11A (NB100-276). Image merged from DAPI (2ms) and Texas ...read more
Proximity Ligation Assay: Mre11 Antibody [NB100-276] - Secondary-conjugate Duolink II PLA in Hela cells. goat anti-human BLM (NB100-324) and rabbit anti-human MRE11A (NB100-276).Image merged from DAPI (2ms) and Texas ...read more
81 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
ATLDmeiotic recombination (S. cerevisiae) 11 homolog A
DNA recombination and repair protein
double-strand break repair protein MRE11A
Meiotic recombination 11 homolog 1
Meiotic recombination 11 homolog A
MRE11 homolog 1
MRE11 homolog A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions (1). This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
The MRE11 Complex and DNA Damage Response The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra... Read full blog post.
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