Mre11 Antibody

Images

 
Western Blot: Mre11 Antibody [NB100-276] - Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Mre11a antibody used for WB at 0.4 ug/ml. ...read more
Immunohistochemistry: Mre11 Antibody [NB100-276] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- Mre11 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Western Blot: Mre11 Antibody [NB100-276] - Whole cell lysate (5, 15 and 50 ug) from HeLa cells. Antibody used at 0.1 ug/ml.
Immunohistochemistry-Paraffin: Mre11 Antibody [NB100-276] - FFPE section of human basal cell carcinoma. Affinity purified rabbit anti-Mre11 used at a dilution of 1:250. Detection: DAB staining using ...read more
Proximity Ligation Assay: Mre11 Antibody [NB100-276] - Secondary-conjugate Duolink II PLA in Hela cells. goat anti-human ATM (NB100-271) and rabbit anti-human MRE11A (NB100-276). Image merged from DAPI (2ms) and Texas ...read more
Proximity Ligation Assay: Mre11 Antibody [NB100-276] - Secondary-conjugate Duolink II PLA in Hela cells. goat anti-human BLM (NB100-324) and rabbit anti-human MRE11A (NB100-276).Image merged from DAPI (2ms) and Texas ...read more

Product Details

Summary
Product Discontinued
View other related Mre11 Primary Antibodies

Order Details


    • Catalog Number
      NB100-276
    • Availability
      Product Discontinued

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Mre11 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human Meiotic Recombination 11 homolog A using the numbering given in entry NP_005582.1 (GeneID 4361).
Clonality
Polyclonal
Host
Rabbit
Gene
MRE11A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:5000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Proximity Ligation Assay 1:1000-1:10000
Theoretical MW
81 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
HeLa Lysate (NB800-PC9)
Mre11 Lysate (NBL1-13219)
Publications
Read Publications using
NB100-276 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Mre11 Antibody

  • ATLDmeiotic recombination (S. cerevisiae) 11 homolog A
  • AT-like disease
  • DNA recombination and repair protein
  • double-strand break repair protein MRE11A
  • endo/exonuclease Mre11
  • HNGS1
  • Meiotic recombination 11 homolog 1
  • Meiotic recombination 11 homolog A
  • MRE11 homolog 1
  • MRE11 homolog A
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
  • Mre11
  • MRE11A
  • MRE11MRE11B

Background

The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions (1). This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Mre11 Antibody (NB100-276)(3)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Mre11 Antibody (NB100-276)

Discover related pathways, diseases and genes to Mre11 Antibody (NB100-276). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Mre11 Antibody (NB100-276)

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Pathways for Mre11 Antibody (NB100-276)

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Research Areas for Mre11 Antibody (NB100-276)

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Blogs on Mre11.

The MRE11 Complex and DNA Damage Response
The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra...  Read full blog post.

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Bioinformatics

Gene Symbol MRE11A
Entrez
Uniprot