Moesin Antibody

Images

 
Western Blot: Moesin Antibody [NBP1-19419] - Extracts from A549 cells.
Immunohistochemistry: Moesin Antibody [NBP1-19419] - Human pancreas tissue.
Western Blot: Moesin Antibody [NBP1-19419] - extracts from NIH/3T3 cells.

Product Details

Summary
Product Discontinued
View other related Moesin Primary Antibodies

Order Details


    • Catalog Number
      NBP1-19419
    • Availability
      Product Discontinued

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Moesin Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 520-570 of Human Moesin.
Clonality
Polyclonal
Host
Rabbit
Gene
MSN
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Moesin (D554) pAb in extracts from A549 cells.
Immunohistochemistry (IHC) analyzes of Moesin (D554) pAb in paraffin-embedded human pancreas tissue.
Theoretical MW
78 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Moesin Antibody

  • Membrane-organizing extension spike protein
  • moesin

Background

Moesin is a member of the ERM (Ezrin-Radixin-Moesin) protein family, which possesses structural and probably functional relationships; they function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains of the plasma membrane and are all localized to the submembranous cytoskeleton. Moesin is widely expressed in different tissues in cells, where it is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signalling and for cell movement. The antibody has been used to inhibit both the binding of proteoheparan sulfate to smooth muscle cells, and the infectivity of measles virus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Moesin Antibody (NBP1-19419). (Showing 1 - 1 of 1 FAQ).

  1. I am looking to use shRNA to inhibit Moesin expression. I have had people advise me that my initial MOI should be low as 'less is more' and 'a little goes a long way' in terms of siRNA. I was wondering if you could elaborate on this for me and explain why my initial MOI should be low.
    • The reason for a low MOI is most likely because RNAi is a very strong and efficient technique. Wikipedia does a good job of explaining <a href="http://en.wikipedia.org/wiki/RNA_interference" target="_blank">RNA interference</a>. However, I would imagine that in a cell, there will be at most 1-2 copies of the gene mRNA present at any given time, unless you're dealing with a highly expressed protein such as Actin, where I would imagine silencing Actin would be lethal to the cell. I can imagine a few reasons to not use too much siRNA. First, it is expensive, so you don't want to waste it. Second, using too much would cause there to be a lot of non-translatable RNA present in the cell, which could trigger an immune response, as the presence of uncapped RNAs can indicate presence of a virus and one of the TLRs may respond to this.

Secondary Antibodies

 

Isotype Controls

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Contact Information

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Bioinformatics

Gene Symbol MSN
Entrez