MMP23 Antibody Summary
Synthetic peptide, corresponding to amino acids 341-390 of Human MMP-23.
Immunogen affinity purified
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- Western Blot 1:500-1:1000
Western blot (WB) analysis of MMP-23 (V371) pAb in extracts from SKOV3 cells.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.05% Sodium Azide
Immunogen affinity purified
Alternate Names for MMP23 Antibody
- EC 3.4.24.-
- matrix metallopeptidase 23A (pseudogene)
- matrix metallopeptidase 23A
- matrix metalloproteinase 23A
- Matrix metalloproteinase-21
- Matrix metalloproteinase-22
Matrix metalloproteinases (MMPs) are highly homologous Zn2+ endopeptidases involved in extracellular matrix breakdown. MMP mediated extracellular remodeling occurs in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, including arthritis and metastasis. MMP-23 exhibits sequence similarity with most MMPs, but displays a difference in domain structure. The MMP-23 protein contains prepro-, catalytic, cysteine-rich, Interleukin-1 receptor-related and proline-rich domains. Lacking a recognizable signal sequence, MMP-23 has a short prodomain. In addition, MMP-23 contains a single cysteine residue that can be part of the cysteine-switch mechanism operation for maintaining enzyme latency. MMP-23 is a membrane-anchored glycoprotein with type II topology. Subcellular localization is predominantly perinuclear. A dramatic switch in MMP-23 mRNA localization from granulosa cells to theca-externa/ fibroblasts and ovarian surface epithelium occurs during follicular development. MMP-23 is expressed in ovary, testis and prostate, suggesting that MMP-23 plays a specialized role in the reproductive processes. The human MMP-23 gene maps to chromosome 1p36.3
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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