MMP-3 Antibody (MM0021-3E44) Summary
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant MMP-3).
Mesenchymal Cells Marker
Protein G purified
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- Western Blot 1:500-1:1000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:200-400
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS
Protein G purified
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.
Alternate Names for MMP-3 Antibody (MM0021-3E44)
- EC 3.4.24
- EC 188.8.131.52
- matrix metallopeptidase 3 (stromelysin 1, progelatinase)
- matrix metalloproteinase 3 (stromelysin 1, progelatinase)
- Matrix metalloproteinase-3
- Stromelysin 1
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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