Recombinant Human MMP-12 Protein

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Product Details

Summary
Product Discontinued
View other related MMP-12 Peptides and Proteins

Order Details


    • Catalog Number
      H00004321-Q01
    • Availability
      Product Discontinued

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Recombinant Human MMP-12 Protein Summary

Protein/Peptide Type
Partial Recombinant Protein
Gene
MMP12

Applications/Dilutions

Application Notes
Useful in Western Blot and ELISA. This protein has not been tested for any functionality. This product may contain endotoxins and is not suitable for use with live cells.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human MMP-12 Protein

  • EC 3.4.24
  • hME
  • HMEEC 3.4.24.65
  • Macrophage elastase
  • macrophage metalloelastase
  • matrix metallopeptidase 12 (macrophage elastase)
  • matrix metalloproteinase 12 (macrophage elastase)
  • Matrix metalloproteinase-12
  • ME
  • MGC138506
  • MME
  • MMP12
  • MMP-12

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Video Protocols

WB Video Protocol

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Bioinformatics Tool for MMP-12 Partial Recombinant Protein (H00004321-Q01)

Discover related pathways, diseases and genes to MMP-12 Partial Recombinant Protein (H00004321-Q01). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for MMP-12 Partial Recombinant Protein (H00004321-Q01)

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Pathways for MMP-12 Partial Recombinant Protein (H00004321-Q01)

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Blogs on MMP-12.

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Monocyte chemotractant protein-1 (MCP-1), also known as CCL2, is a key chemokine involved in the migration of monocytes and macrophages to sites of active inflammation. It is a member of the C-C/beta family of cytokines, characterized by the Cys-C...  Read full blog post.

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Bioinformatics

Gene Symbol MMP12
Entrez