MMP-1 Antibody (SB12e)

Product Discontinued

MMP-1 Antibody (SB12e) Summary

• Immunogen: Full-length recombinant MMP-1.
• Specificity: Human MMP-1; Does not cross react to human MMP-2, MMP-3 or MMP-9
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MMP1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:3000-1:8000
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen < = 2 ug/ml
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: BBS (pH 8.2)
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: Protein A or G purified

Alternate Names for MMP-1 Antibody (SB12e)

• CLGmatrix metalloprotease 1
• CLGN
• EC 3.4.24
• EC 3.4.24.7
• Fibroblast collagenase
• interstitial collagenase
• matrix metallopeptidase 1 (interstitial collagenase)
• matrix metalloproteinase 1 (interstitial collagenase)
• Matrix metalloproteinase-1
• MMP1
• MMP-1

Background

Matrix metalloproteinases (MMPs) are a family of at least 20 structurally related, zinc-containing enzymes that have the ability to breakdown connective tissue. MMP-1 is also known as collagenase, fibroblast collagenase, and interstitial collagenase. MMP-1 has shown substrate specificity to collagens I, II, III, VII. VIII and X, aggrecan, versican, tenascin, casein, gelatin, alpha 1-antitrypsin, myelin basic protein, L-selectin, pro-TNF, IL-1 beta, pro-MMP-2 and pro-MMP-9 directly and indirectly by activating other MMPs. (1-15)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MMP-1 Antibody (NBP1-28604)(2)

Publications using NBP1-28604

• Singh M, Kindelberger D, Nagymanyoki Z et al. Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta Gynecol Oncol 2011-07-01 [PMID: 21514631] (IF/IHC, Human)
• Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01

Bioinformatics

• Gene Symbol: MMP1
• Entrez:
  • 4312(Human)
• Uniprot:
  • P03956()