MLX Antibody

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Western Blot: MLX Antibody [NB100-92408] - Analysis of Mlx (Q136) antibody in extracts from LOVO cells.

Product Details

Summary
Product Discontinued
View other related MLX Primary Antibodies

Order Details


    • Catalog Number
      NB100-92408
    • Availability
      Product Discontinued

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MLX Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 102-150 of Human Mlx.
Clonality
Polyclonal
Host
Rabbit
Gene
MLX
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Theoretical MW
33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MLX Antibody

  • BHLHD13
  • bHLHd13Max-like bHLHZip protein
  • BigMax alpha
  • BigMax protein
  • Class D basic helix-loop-helix protein 13
  • MAD7
  • MAX-like protein X
  • MLX
  • MXD7
  • TCFL4
  • TCFL4Protein BigMax
  • transcription factor-like 4
  • Transcription factor-like protein 4

Background

Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad 1, Mad 3, Mad 4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. MLX (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, MLX is broadly expressed in many tissues and has a long half-life. MLX also forms homodimers or heterodimers with members of the Myc family, specifically Mad 1, Mad 4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with MLX. The MondoA/MLX complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. MLX can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that MLX is a critical element in a transcription factor network.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional MLX Products

Bioinformatics Tool for MLX Antibody (NB100-92408)

Discover related pathways, diseases and genes to MLX Antibody (NB100-92408). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for MLX Antibody (NB100-92408)

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Pathways for MLX Antibody (NB100-92408)

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PTMs for MLX Antibody (NB100-92408)

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Blogs on MLX.

ChREBP, a glucose sensitive transcription factor with role in glucose-lipids homeostasis and cancer
ChREBP (carbohydrate response element-binding protein) is a glucose responsive basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that binds MLX and then carbohydrate response element /ChoRE for the induction of genes involved in...  Read full blog post.

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Bioinformatics

Gene Symbol MLX
Entrez
Uniprot