Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Phosphate buffered saline, pH 7.2.
0.05% Sodium Azide
Immunogen affinity purified
Western blot (WB) analysis of MEK4 (S80) pAb in extracts from NIH/3T3 cells. Immunohistochemistry (IHC) analyzes of MEK4 (S80) pAb in paraffin-embedded human breast carcinoma tissue
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
dual specificity mitogen-activated protein kinase kinase 4
JNK activating kinase 1
JNK-activated kinase 1
JNK-activating kinase 1
JNKK1MAPK/ERK kinase 4
MAP kinase kinase 4
mitogen-activated protein kinase kinase 4
MKK4SAPK/ERK kinase 1
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK-5, whereas MEK-6 phosphorylates p38 and p38beta. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.