MKK4/MEK4 [p Ser80] Antibody

Images

 
Western Blot: MEK4 Antibody [NB100-92624] - Western blot (WB) analysis of MEK4 (S80) antibody in extracts from NIH/3T3 cells.
Immunohistochemistry: MEK4 Antibody [NB100-92624] - Immunohistochemistry (IHC) analyzes of MEK4 (S80) antibody in paraffin-embedded human breast carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-92624
    • Availability
      Product Discontinued

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MKK4/MEK4 [p Ser80] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human MEK-4 around the phosphorylation site of Serine 80.
Modification
p Ser80
Specificity
p-SEK1/MKK4 (S80) detects endogenous levels of p-SEK1/MKK4 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
MAP2K4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of MEK4 (S80) pAb in extracts from NIH/3T3 cells.
Immunohistochemistry (IHC) analyzes of MEK4 (S80) pAb in paraffin-embedded human breast carcinoma tissue
Theoretical MW
44 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NB100-92624.

Reactivity Notes

This antibody is reactive against Human, Mouse,.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MKK4/MEK4 [p Ser80] Antibody

  • c-Jun N-terminal kinase kinase 1
  • dual specificity mitogen-activated protein kinase kinase 4
  • JNK activating kinase 1
  • JNK-activated kinase 1
  • JNK-activating kinase 1
  • JNKK
  • JNKK1
  • JNKK1MAPK/ERK kinase 4
  • MAP kinase kinase 4
  • MAP2K4
  • MAPKK4
  • MEK4
  • MEK4MEK 4
  • mitogen-activated protein kinase kinase 4
  • MKK4
  • MKK4SAPK/ERK kinase 1
  • PRKMK4
  • PRKMK4MAPKK 4
  • SEK1
  • SERK1
  • SERK1EC 2.7.12.2

Background

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK-5, whereas MEK-6 phosphorylates p38 and p38beta. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MKK4/MEK4 Antibody (NB100-92624)(1)

We have publications tested in 1 confirmed species: Human.


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Bioinformatics

Gene Symbol MAP2K4
Entrez