MKK3/MEK3 Overexpression Lysate (Denatured)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB

Order Details

MKK3/MEK3 Overexpression Lysate (Denatured) Summary

Description
Pasmid: pCMV-MAP2K3 full-length
Gene
MAP2K3

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).

Lysate Details for MKK3/MEK3

Type
Overexpression
Protein State
Denatured

Notes

Quality control test: Transient overexpression cell lysate was tested with Anti-MAP2K3 antibody by Western Blots.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MKK3/MEK3 Overexpression Lysate (Denatured)

  • MAP kinase kinase 3
  • MAP2K3
  • MAPK/ERK kinase 3
  • MAPKK 3
  • MAPKK3PRKMK3dual specificity mitogen-activated protein kinase kinase 3
  • MEK3
  • MEK3MEK 3
  • mitogen activated protein kinase kinase 3
  • mitogen-activated protein kinase kinase 3
  • MKK3
  • MKK3EC 2.7.12.2
  • PRKMK3

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq]. Transcript Variant: This variant (B) represents the longer transcript and it encodes the longer protein (isoform B). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

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Publications for MKK3/MEK3 Lysate (H00005606-T01) (0)

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Bioinformatics

Gene Symbol MAP2K3
Entrez