MKK3/MEK3 Antibody

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Western Blot: MKK3/MEK3 Antibody [NBP1-51313] - Analysis of MEK3 (L215) pAb in extracts from Jurkat cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51313
    • Availability
      Product Discontinued

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MKK3/MEK3 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 200-250 of Human MEK-3.
Specificity
MEK-3 (L215) pAb detects endogenous levels of MEK-3 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
MAP2K3
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of MEK-3 (L215) pAb in extracts from Jurkat cells.
Theoretical MW
39 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (approx. pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MKK3/MEK3 Antibody

  • MAP kinase kinase 3
  • MAP2K3
  • MAPK/ERK kinase 3
  • MAPKK 3
  • MAPKK3PRKMK3dual specificity mitogen-activated protein kinase kinase 3
  • MEK3
  • MEK3MEK 3
  • mitogen activated protein kinase kinase 3
  • mitogen-activated protein kinase kinase 3
  • MKK3
  • MKK3EC 2.7.12.2
  • PRKMK3

Background

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase egulatory threonine and tyrosine residues present in the hr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 hosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MAP2K3
Entrez