Mitofusin 1 Antibody

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Immunohistochemistry-Paraffin: Mitofusin 1 Antibody [NBP1-52469] - Analysis of anti-MFN1 antibody with human adrenal at concentration 3.75 ug/ml.
Immunohistochemistry-Paraffin: Mitofusin 1 Antibody [NBP1-52469] - Analysis of anti-MFN1 antibody with human uterus at concentration 3.75 ug/ml.

Product Details

Summary
Reactivity Hu, Ca, Eq, Mk, Rb, Mu, Rt, Bv, PmSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Mitofusin 1 Antibody Summary

Immunogen
Synthetic peptide C-NKAVQLENELEN from an internal region of human MFN1 (NP_284941.2).
Marker
Mitochondrial Fusion Marker
Specificity
Human MFN1.
Predicted Species
Mouse (92%), Rat (92%), Primate (92%), Bovine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
MFN1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 3.75 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Marmoset (100%), Elephant (100%), Bat (83%), Platypus (83%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Mitofusin 1 Antibody

  • DKFZp762F247
  • EC 3.6.5
  • EC 3.6.5.-
  • FLJ20693
  • Fzo homolog
  • hfzo1
  • hfzo2
  • MFN1
  • MGC41806
  • mitochondrial transmembrane GTPase Fzo-1
  • mitochondrial transmembrane GTPase FZO-2
  • Mitofusin 1
  • mitofusin-1
  • putative transmembrane GTPase
  • Transmembrane GTPase MFN1

Background

When mitochondria are impaired by genetic mutations or viral insertions, they are selectively isolated and destroyed by complicated intracellular mechanisms. The mitochondrial fusion-promoting factor MFN1 is a critical contributor to mediating this selective process. MFN1 is ubiquinated by PINK1 after its recruitment by Parkin, and this post-translational modification is critical in catalyzing mitochondrial repair or removal by other cellular mechanisms. In both Parkinson's and Alzheimer's disease, as well as when viruses attempt to replicate, mitochondrial fission and mitophagy are erroneously regulated due to the mutation or elimination of MFN1. This disruption of mitochondrial repair and regulation is implicated in many of the phenotypic demonstrations of neurodegenerative disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MFN1
Entrez
Uniprot